Description

trans-(4-(Methylamino)Cyclohexyl)Methanesulfonic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique cyclohexylmethanesulfonic acid scaffold with a trans-configured methylamino substituent. This compound is valued for its role as a critical building block in the synthesis of novel, small-molecule therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery pipelines. Its precise stereochemistry and functional group arrangement make it an essential reagent for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for targeted cancer therapies and neurological disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to introduce specific pharmacophoric elements into candidate molecules.
• Process Chemistry & Scale-up: Serves as a starting material or intermediate in the development of robust, scalable synthetic routes for GMP manufacturing.
• Protease Inhibitor Synthesis: Potential application in constructing molecules that mimic transition states for enzyme inhibition, given the sulfonic acid moiety.
• Ligand and Catalyst Development: The methylamino group can be utilized to create novel ligands for asymmetric catalysis or metal complexes.
• Academic & Institutional Research: Employed in chemical biology and drug discovery programs within university and government research laboratories.

Basic Information

Product Name	trans-(4-(Methylamino)Cyclohexyl)Methanesulfonic Acid
CAS No.	2124221-12-9
Molecular Formula	C8H17NO3S
Molecular Weight	207.29 g/mol
Synonyms	trans-4-(Methylamino)cyclohexylmethanesulfonic Acid; (1r,4r)-4-(Methylamino)cyclohexane-1-sulfonic Acid; 4-(Methylamino)cyclohexanesulfonic Acid (trans-); 4-(Methylamino)-1-cyclohexanesulfonic Acid; 4-(Methylamino)cyclohexylsulfonic Acid; (trans-4-(Methylamino)cyclohexyl)methanesulfonate; 2124221-12-9; UNII-Contact for details
EINECS	Contact for details

Quality Control

Our trans-(4-(Methylamino)Cyclohexyl)Methanesulfonic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical R&D and pre-clinical development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support compliance with ICH Q7 guidelines and can provide material suitable for use under GMP conditions upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (trans-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.