Description

4-Benzyloxy-3-Chloro-5-Fluorobenzeneboronic Acid Pinacol Ester is a high-purity, synthetically valuable boronic ester derivative. This compound serves as a critical building block in modern organic synthesis, particularly for the construction of complex molecules via cross-coupling reactions. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-quality intermediates for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides that require specific halogenated and benzyl-protected aromatic structures.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLEDs and semiconductors, where precise molecular architecture is crucial.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the development of molecular probes and inhibitors.
• Academic & Industrial R&D: Serves as a fundamental reagent for methodological development in synthetic organic chemistry laboratories worldwide.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke fine chemicals for client projects.

Basic Information

Product Name	4-Benzyloxy-3-Chloro-5-Fluorobenzeneboronic Acid Pinacol Ester
CAS No.	2121515-13-5
Molecular Formula	C19H21BClFO3
Molecular Weight	362.63 g/mol
Synonyms	4-(Benzyloxy)-3-chloro-5-fluorobenzeneboronic acid pinacol ester; (4-(Benzyloxy)-3-chloro-5-fluorophenyl)boronic acid pinacol ester; 3-Chloro-5-fluoro-4-(phenylmethoxy)benzeneboronic acid pinacol ester; B-[4-(Benzyloxy)-3-chloro-5-fluorophenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-[4-(phenylmethoxy)-3-chloro-5-fluorophenyl]-1,3,2-dioxaborolane; 2121515-13-5; Boronic acid, B-[4-(benzyloxy)-3-chloro-5-fluorophenyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 4-Benzyloxy-3-Chloro-5-Fluorobenzeneboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for demanding synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable and can provide material to meet specific customer specifications for advanced R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC, Area%)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.