Description

5-Bromo-2-Chloropyridine-4-Boronic Acid, Pinacol Ester is a high-value, multi-functional boronic ester building block essential for modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecular architectures. This advanced intermediate is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific halogenated pyridine scaffolds.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of organic electronic materials, such as OLEDs and conductive polymers.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes, bioconjugation linkers, and tags for studying biological processes.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura couplings to introduce the 4-boronic ester-substituted pyridine moiety into target molecules.
• Library Synthesis for Drug Discovery: A versatile scaffold for generating diverse compound libraries via parallel and combinatorial chemistry approaches in high-throughput screening.

Basic Information

Product Name	5-Bromo-2-Chloropyridine-4-Boronic Acid, Pinacol Ester
CAS No.	2121514-81-4
Molecular Formula	C11H14BBrClNO2
Molecular Weight	318.40 g/mol
Synonyms	5-Bromo-2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-Chloro-5-bromo-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-bromo-2-chloropyridine; 5-Bromo-2-chloropyridine-4-boronic acid pinacol ester; (5-Bromo-2-chloropyridin-4-yl)boronic acid pinacol ester; B-(5-Bromo-2-chloro-4-pyridinyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Chloropyridine-4-Boronic Acid, Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, typically ≥95% (by HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation via spectroscopic methods (NMR, IR), and impurity profiles. We adhere to cGMP principles where applicable, supporting our commitment to supplying reliable building blocks for critical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability. Keep the container tightly sealed in a dry environment to prevent moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.