Description

4-Butoxy-2-Fluorophenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron building block. This compound is critical for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex fluorinated biaryl structures.

Application

• Pharmaceutical Intermediate: A key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the fluorinated biaryl moiety imparts specific biological activity.
• Material Science Research: Serves as a precursor for creating functionalized organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) with tailored electronic or optical properties.
• Cross-Coupling Reactions: Specifically designed as a stable, air-handleable boronic ester for palladium-catalyzed Suzuki-Miyaura cross-coupling with various aryl/heteroaryl halides.
• Chemical Biology Probes: Employed in the synthesis of fluorinated molecular probes and tags for imaging and diagnostic applications.

Basic Information

Product Name	4-Butoxy-2-Fluorophenylboronic Acid Pinacol Ester
CAS No.	2121514-65-4
Molecular Formula	C₁₆H₂₄BFO₃
Molecular Weight	294.17 g/mol
Synonyms	2-Fluoro-4-butoxyphenylboronic acid pinacol ester; 4-Butoxy-2-fluorobenzeneboronic acid pinacol ester; (4-Butoxy-2-fluorophenyl)boronic acid pinacol ester; 2-Fluoro-4-n-butoxyphenylboronic acid pinacol ester; 4-n-Butoxy-2-fluorophenylboronic acid pinacol ester; Pinacol (4-butoxy-2-fluorophenyl)boronate; 4-Butoxy-2-fluorophenyl-Bpin
EINECS	Contact for details

Quality Control

Our 4-Butoxy-2-Fluorophenylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive coupling reactions. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity and impurity profiles. Our quality management system supports compliance with cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.