Description

2-Aminopyridine-5-Boronic Acid Pinacol Ester Hydrochloride is a high-value, multifunctional chemical building block essential for modern synthetic chemistry. Its core value lies in its dual functionality, combining a protected boronic acid group for Suzuki-Miyaura cross-coupling reactions with an amine group for further derivatization, enabling the rapid construction of complex heterocyclic scaffolds. This compound is primarily needed by researchers and process chemists in the pharmaceutical, agrochemical, and material science industries for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound libraries.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science Precursor: Serves as a monomer or linker for creating advanced organic electronic materials, such as those used in OLEDs and sensors.
• Cross-Coupling Reactions: The pinacol-protected boronic ester moiety is specifically designed for robust, palladium-catalyzed Suzuki-Miyaura cross-coupling under mild conditions.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological processes and target engagement.
• Ligand Synthesis: The aminopyridine core can be functionalized to create novel ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	2-Aminopyridine-5-Boronic Acid Pinacol Ester Hydrochloride
CAS No.	2121514-56-3
Molecular Formula	C11H18BClN2O2
Molecular Weight	256.54 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine hydrochloride; 2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine hydrochloride; 2-Amino-5-(pinacolatoboryl)pyridine HCl; 2-Amino-5-pyridineboronic acid pinacol ester hydrochloride; 5-Borono-2-aminopyridine pinacol ester hydrochloride; 2-APB-Pinacol Ester HCl; 2-Amino-5-boronopyridine pinacol ester hydrochloride salt
EINECS	Contact for details

Quality Control

Our 2-Aminopyridine-5-Boronic Acid Pinacol Ester Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our standard quality commitment aligns with the requirements for fine chemical and pharmaceutical intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and desiccated to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.