Description

5-Bromobenzo[1,3]Dioxole-4-Boronic Acid Pinacol Ester is a high-purity, synthetically valuable boronic ester derivative, serving as a crucial Suzuki-Miyaura cross-coupling building block. Its core value lies in enabling the efficient, palladium-catalyzed formation of carbon-carbon bonds, which is fundamental for constructing complex molecular architectures. This advanced intermediate is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for synthesizing novel active compounds and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting complex heterocyclic structures.
• Agrochemical Synthesis: Used in the research and development of new active ingredients for crop protection products.
• Material Science Research: Employed in the creation of organic electronic materials, such as polymers and small molecules for OLEDs or OFETs.
• Chemical Biology Probes: Serves as a precursor for labeling reagents or probe molecules used in biochemical assays.
• Catalyst Ligand Precursor: Can be utilized to synthesize novel ligand frameworks for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	5-Bromobenzo[1,3]Dioxole-4-Boronic Acid Pinacol Ester
CAS No.	2121514-16-5
Molecular Formula	C₁₃H₁₆BBrO₄
Molecular Weight	327.98 g/mol
Synonyms	5-Bromo-1,3-benzodioxole-4-boronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-(5-bromobenzo[d][1,3]dioxol-4-yl)-1,3,2-dioxaborolane; (5-Bromobenzo[d][1,3]dioxol-4-yl)boronic acid pinacol ester; 5-Bromopiperonylboronic acid pinacol ester; 5-Bromo-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-benzodioxole; Boronic acid, B-(5-bromo-1,3-benzodioxol-4-yl)-, 1,1-dimethylethyl ester (9CI)
EINECS	Contact for details

Quality Control

Our 5-Bromobenzo[1,3]Dioxole-4-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic nature. Allow the sealed container to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.