Description

2-Amino-3,5-Dimethylphenylboronic Acid, Pinacol Ester is a specialized organoboron building block, a protected form of the corresponding boronic acid, designed for enhanced stability and handling in advanced synthesis. This compound is critical for enabling key carbon-carbon bond-forming reactions, such as the Suzuki-Miyaura cross-coupling, which is fundamental to modern pharmaceutical and agrochemical research. It is primarily utilized by R&D chemists and process development scientists in the life sciences sector for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates containing biaryl or heterobiaryl motifs.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides through palladium-catalyzed cross-coupling methodologies.
• Material Science: Serves as a monomer or precursor in the creation of organic electronic materials, such as polymers for OLEDs or conductive films.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and sensors that utilize boronic acid-diol interactions for detection.
• Academic & Contract Research: Essential reagent for methodological development in synthetic organic chemistry laboratories worldwide.
• Scale-up Process Chemistry: The pinacol ester protection offers improved handling and shelf-life for large-scale manufacturing processes compared to the free boronic acid.

Basic Information

Product Name	2-Amino-3,5-Dimethylphenylboronic Acid, Pinacol Ester
CAS No.	2121514-04-1
Molecular Formula	C14H22BNO2
Molecular Weight	247.14 g/mol
Synonyms	2-Amino-3,5-dimethylbenzeneboronic acid pinacol ester; (2-Amino-3,5-dimethylphenyl)boronic acid pinacol ester; 2-Amino-3,5-dimethylphenylboronic acid neopentyl glycol ester; B-(2-Amino-3,5-dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-(2-amino-3,5-dimethylphenyl)-1,3,2-dioxaborolane; 2-(2-Amino-3,5-dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Boronic acid, B-(2-amino-3,5-dimethylphenyl)-, 1,1-dimethylethyl ester (9CI); CAS 2121514-04-1
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Quality Control

Our 2-Amino-3,5-Dimethylphenylboronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and may require storage under an inert atmosphere for long-term stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.