Description

2-Bromo-4-(Trifluoromethoxy)Phenylboronic Acid Pinacol Ester is a high-value, organoboron building block crucial for modern synthetic chemistry. This compound, with CAS number 2121514-01-8, is specifically engineered for use in palladium-catalyzed cross-coupling reactions, such as the Suzuki-Miyaura reaction, enabling the efficient construction of complex biaryl structures. It is an essential intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and reliable synthetic pathways.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethoxy and bromo substituents for enhanced bioactivity and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the boronic ester group facilitates the introduction of complex aromatic systems.
• Material Science Research: Serves as a precursor for creating organic electronic materials, including ligands for catalysts and monomers for specialty polymers.
• Chemical Biology & Medicinal Chemistry: Employed in the discovery and development of new drug candidates through combinatorial chemistry and library synthesis.
• Custom Synthesis & Contract Manufacturing: A critical reagent for fine chemical and custom synthesis organizations serving the life sciences industry.

Basic Information

Product Name	2-Bromo-4-(Trifluoromethoxy)Phenylboronic Acid Pinacol Ester
CAS No.	2121514-01-8
Molecular Formula	C₁₃H₁₅BBrF₃O₃
Molecular Weight	366.97 g/mol
Synonyms	2-Bromo-4-(trifluoromethoxy)benzeneboronic acid pinacol ester; [2-Bromo-4-(trifluoromethoxy)phenyl]boronic acid pinacol ester; 4-Bromo-2-(trifluoromethoxy)phenylboronic acid pinacol ester; Pinacol 2-Bromo-4-(trifluoromethoxy)phenylboronate; B-[2-Bromo-4-(trifluoromethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-Bromo-4-(trifluoromethoxy)phenylboronic acid, pinacol ester; 2121514-01-8
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-4-(Trifluoromethoxy)Phenylboronic Acid Pinacol Ester is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent oxidation and hydrolysis. For long-term storage, consider storing under an inert gas in a freezer (-20°C).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.