Description

2-Amino-3-Chloro-5-Methylphenylboronic Acid, Pinacol Ester is a high-purity, synthetically valuable boronic ester derivative, serving as a protected and stabilized form of the corresponding boronic acid. This compound is a critical advanced pharmaceutical intermediate (API intermediate) for constructing complex molecules via Suzuki-Miyaura cross-coupling reactions. It is essential for research and production in pharmaceutical development, agrochemical synthesis, and advanced materials science, where precise molecular architecture is required.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides requiring specific chlorinated aniline derivatives.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLEDs and organic semiconductors, where the pinacol ester group offers enhanced stability.
• Chemical Synthesis & Catalysis: Serves as a versatile reagent in palladium-catalyzed cross-coupling reactions to form biaryl and heterobiaryl structures.
• Ligand & Catalyst Development: Utilized as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Diagnostic Reagent Manufacturing: Potential use in synthesizing probes and sensors for biochemical detection and imaging.

Basic Information

Product Name	2-Amino-3-Chloro-5-Methylphenylboronic Acid, Pinacol Ester
CAS No.	2121513-87-7
Molecular Formula	C13H19BClNO2
Molecular Weight	267.56 g/mol
Synonyms	2-Amino-3-chloro-5-methylbenzeneboronic acid pinacol ester; (2-Amino-3-chloro-5-methylphenyl)boronic acid pinacol ester; 2-Chloro-6-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline; 3-Chloro-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline; B-(2-Amino-3-chloro-5-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2121513-87-7; Boronic acid, B-(2-amino-3-chloro-5-methylphenyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 2-Amino-3-Chloro-5-Methylphenylboronic Acid, Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Production adheres to cGMP guidelines where applicable. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with global regulatory standards including REACH.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.