Description

2-Bromo-3-Trifluoromethylphenylboronic Acid Pinacol Ester is a high-value, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the precise construction of complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds to create biaryl structures, a common motif in drug discovery.
• Pharmaceutical Intermediate Synthesis: Used in the research and development of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethyl and halogenated aromatic groups.
• Agrochemical Research: Employed in the synthesis of novel herbicides, fungicides, and insecticides that require specific halogenated aromatic components.
• Material Science Precursor: Acts as a monomer or building block for advanced organic electronic materials, such as OLEDs or semiconductors.
• Chemical Biology & Probe Development: Useful for creating tagged molecules or probes for studying biological systems and target engagement.
• Process Chemistry & Scale-Up: The pinacol ester group offers enhanced stability, making it suitable for multi-step synthesis and larger-scale manufacturing processes.

Basic Information

Product Name	2-Bromo-3-Trifluoromethylphenylboronic Acid Pinacol Ester
CAS No.	2121513-56-0
Molecular Formula	C₁₃H₁₅BBrF₃O₂
Molecular Weight	350.97 g/mol
Synonyms	2-Bromo-3-(trifluoromethyl)benzeneboronic acid pinacol ester; (2-Bromo-3-(trifluoromethyl)phenyl)boronic acid pinacol ester; 2-Bromo-α,α,α-trifluoro-m-tolylboronic acid pinacol ester; B-[2-Bromo-3-(trifluoromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol (2-Bromo-3-trifluoromethylphenyl)boronate; 2-Bromo-3-trifluoromethylbenzeneboronic acid, pinacol ester; CAS 2121513-56-0
EINECS	Contact for details

Quality Control

Our 2-Bromo-3-Trifluoromethylphenylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management principles, and our analytical methods, including NMR and HPLC, are validated to provide reliable specifications for our customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.