Description

7-Methyl-1H-Indazole-5-Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. Its core value lies in its role as a protected boronic acid derivative, offering enhanced stability and solubility for critical cross-coupling reactions, most notably the Suzuki-Miyaura reaction. This compound is essential for researchers and manufacturers in medicinal chemistry, particularly those developing novel small-molecule therapeutics, agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially those containing the indazole heterocycle, which is prevalent in kinase inhibitors and other targeted therapies.
• Suzuki-Miyaura Cross-Coupling: Serves as a crucial coupling partner for the formation of carbon-carbon bonds, enabling the construction of biaryl and heterobiaryl structures central to modern drug discovery.
• Medicinal Chemistry & Drug Discovery: Used in high-throughput screening libraries and structure-activity relationship (SAR) studies to explore new chemical space and optimize lead compounds.
• Agrochemical Research: Employed in the development of new herbicides, fungicides, and insecticides that require specific heterocyclic architectures.
• Material Science: A precursor for creating organic electronic materials, such as OLEDs and semiconductors, where precise molecular engineering is required.
• Chemical Biology & Probe Development: Useful for synthesizing molecular probes and tags for studying biological processes and protein interactions.

Basic Information

Product Name	7-Methyl-1H-Indazole-5-Boronic Acid Pinacol Ester
CAS No.	2121513-33-3
Molecular Formula	C₁₅H₂₁BN₂O₂
Molecular Weight	272.16 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-7-methyl-1H-indazole; 7-Methyl-1H-indazol-5-ylboronic acid pinacol ester; (7-Methyl-1H-indazol-5-yl)boronic acid pinacol ester; 7-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole; Pinacol 7-Methyl-1H-indazole-5-boronate; B-(7-Methyl-1H-indazol-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 7-Methylindazole-5-boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 7-Methyl-1H-Indazole-5-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and cGMP applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.