Description

2-Fluoro-3-Methoxy-4-Pyridineboronic Acid Pinacol Ester CAS NO 2121513-24-2 is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. This compound is valued for its role as a key coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS disorders, oncology, and infectious diseases.
• Suzuki-Miyaura Cross-Coupling Reagent: Serves as a stable, protected boronic ester reagent for palladium-catalyzed C-C bond formation to create complex substituted pyridine derivatives.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require fluorinated pyridine motifs for enhanced activity and stability.
• Material Science Research: Employed in the synthesis of organic electronic materials, ligands for catalysts, and metal-organic frameworks (MOFs) due to its functionalized aromatic core.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Acts as a versatile linker or functional group in the design of bifunctional molecules for targeted protein degradation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical producers for custom synthesis projects requiring specific fluorinated heterocyclic architectures.

Basic Information

Product Name	2-Fluoro-3-Methoxy-4-Pyridineboronic Acid Pinacol Ester
CAS No.	2121513-24-2
Molecular Formula	C₁₂H₁₇BFNO₃
Molecular Weight	253.08 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-fluoro-3-methoxypyridine; 2-Fluoro-3-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; (2-Fluoro-3-methoxypyridin-4-yl)boronic acid pinacol ester; 2-Fluoro-3-methoxy-4-pyridinylboronic acid pinacol ester; 4-Pyridineboronic acid, 2-fluoro-3-methoxy-, 1,3,2-dioxaborolane ester; 2121513-24-2; Boronic acid, B-(2-fluoro-3-methoxy-4-pyridinyl)-, 1,3,2-dioxaborolane ester
EINECS	Contact for details

Quality Control

Our 2-Fluoro-3-Methoxy-4-Pyridineboronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR (¹H, ¹³C, ¹⁹F), and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We adhere to cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for critical R&D and production applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.