Description

4-Bromo-3-Hydroxyphenylboronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block in organic synthesis. Its value lies in its protected boronic acid functionality, which offers enhanced stability for handling and storage compared to the free acid, while remaining a crucial reagent for Suzuki-Miyaura cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who are developing novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Suzuki-Miyaura Cross-Coupling: Serves as a critical electrophilic partner for forming carbon-carbon bonds, enabling the construction of complex biaryl and heterobiaryl structures prevalent in modern drug discovery.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific bromo-hydroxyphenyl motifs.
• Ligand and Catalyst Development: Employed as a precursor for creating specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: A monomer or precursor for synthesizing organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein interactions.

Basic Information

Product Name	4-Bromo-3-Hydroxyphenylboronic Acid Pinacol Ester
CAS No.	2121512-98-7
Molecular Formula	C12H16BBrO3
Molecular Weight	299.0 g/mol
Synonyms	4-Bromo-3-hydroxyphenylboronic acid pinacol ester; (4-Bromo-3-hydroxyphenyl)boronic acid pinacol ester; 2-(4-Bromo-3-hydroxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-Bromo-3-hydroxybenzeneboronic acid pinacol ester; Pinacol (4-Bromo-3-hydroxyphenyl)boronate; B-(4-Bromo-3-hydroxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; CAS 2121512-98-7
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-3-Hydroxyphenylboronic Acid Pinacol Ester is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. Our standard grade meets specifications suitable for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.