Description

5-Chloro-2,4-Dimethoxyphenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable boronic ester derivative. This compound serves as a critical protected intermediate in modern cross-coupling reactions, enabling the precise construction of complex molecules. It is primarily required by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for synthesizing novel active ingredients and functional compounds.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key building block for the palladium-catalyzed formation of carbon-carbon bonds, essential for creating biaryl structures in drug discovery.
• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring substituted phenyl or biphenyl motifs.
• Agrochemical Synthesis: Employed in the research and development of novel herbicides, fungicides, and insecticides.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and other transition metal-catalyzed processes.
• Material Science Research: Utilized in the development of organic electronic materials, such as OLEDs and semiconductors, where specific aryl-aryl linkages are needed.
• Chemical Biology Probes: Acts as a versatile handle for bioconjugation and the synthesis of molecular probes for biological target identification.

Basic Information

Product Name	5-Chloro-2,4-Dimethoxyphenylboronic Acid Pinacol Ester
CAS No.	2121512-49-8
Molecular Formula	C14H20BClO4
Molecular Weight	298.57 g/mol
Synonyms	5-Chloro-2,4-dimethoxyphenylboronic acid pinacol ester; (5-Chloro-2,4-dimethoxyphenyl)boronic acid pinacol ester; 2-(5-Chloro-2,4-dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Chloro-2,4-dimethoxybenzeneboronic acid pinacol ester; Pinacol (5-chloro-2,4-dimethoxyphenyl)boronate; Boronic acid, B-(5-chloro-2,4-dimethoxyphenyl)-, 1,1-dimethylethyl ester (9CI)
EINECS	Contact for details

Quality Control

Our 5-Chloro-2,4-Dimethoxyphenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥97.0%
Purity (GC)	≥98.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.