Description

2-Chloro-4-Fluoro-6-Methylphenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron building block. This compound matters as a critical intermediate in modern cross-coupling reactions, enabling the efficient construction of complex aromatic and heteroaromatic systems. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for synthesizing novel active ingredients.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds to create biaryl structures prevalent in drug molecules.
• Pharmaceutical Intermediate: Used in the research and development of new active pharmaceutical ingredients (APIs), particularly those requiring halogenated, multi-substituted phenyl motifs.
• Agrochemical Synthesis: Serves as a building block for novel herbicides, fungicides, and insecticides where the specific halogen pattern is crucial for bioactivity.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as ligands for catalysts or monomers for conjugated polymers.
• Chemical Library Development: Utilized in parallel and combinatorial chemistry for generating diverse compound libraries for high-throughput screening.
• Process Chemistry & Scale-Up: The pinacol ester form offers improved stability and handling characteristics for large-scale manufacturing processes.

Basic Information

Item	Detail
Product Name	2-Chloro-4-Fluoro-6-Methylphenylboronic Acid Pinacol Ester
CAS No.	2121512-28-3
Molecular Formula	C13H17BClFO2
Molecular Weight	269.54 g/mol
Synonyms	2-Chloro-4-fluoro-6-methylbenzeneboronic acid pinacol ester; (2-Chloro-4-fluoro-6-methylphenyl)boronic acid pinacol ester; 2-Chloro-4-fluoro-6-methylphenyl-Bpin; 4,4,5,5-Tetramethyl-2-(2-chloro-4-fluoro-6-methylphenyl)-1,3,2-dioxaborolane; Boronic acid, B-(2-chloro-4-fluoro-6-methylphenyl)-, 1,1-dimethylethyl ester; 2-Chloro-4-fluoro-6-methylphenylboronic acid neopentyl glycol ester (common alternative); 2-Cl-4-F-6-MeC6H2Bpin
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Fluoro-6-Methylphenylboronic Acid Pinacol Ester is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 19F, 11B), and GC/MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality systems support development from research quantities to commercial scale, ensuring reliable supply for your projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Purity (NMR)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.