Description

2-Chloro-5-Fluoro-3-Methylphenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron building block. This compound is essential for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern pharmaceutical and agrochemical research. It is primarily utilized by R&D chemists and process development scientists in the life sciences sector for constructing complex biaryl and heterobiaryl structures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing complex, multi-substituted biphenyl scaffolds.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where specific halogenated aromatic motifs are required for bioactivity.
• Material Science Research: Serves as a monomer or building block for creating advanced organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis and other organometallic complexes.
• Chemical Biology Probes: Useful in the design and synthesis of molecular probes and tags for studying biological systems and drug-target interactions.
• Custom Synthesis and Contract Manufacturing: Supplied to CROs and CMOs for use in client-directed synthesis projects requiring precise boronic ester coupling partners.

Basic Information

Product Name	2-Chloro-5-Fluoro-3-Methylphenylboronic Acid Pinacol Ester
CAS No.	2121512-19-2
Molecular Formula	C₁₃H₁₇BClFO₂
Molecular Weight	270.54 g/mol
Synonyms	2-Chloro-5-fluoro-3-methylbenzeneboronic acid pinacol ester; (2-Chloro-5-fluoro-3-methylphenyl)boronic acid pinacol ester; 2-Chloro-5-fluoro-3-methylphenylboronic acid, pinacol ester; 4,4,5,5-Tetramethyl-2-(2-chloro-5-fluoro-3-methylphenyl)-1,3,2-dioxaborolane; Boronic acid, B-(2-chloro-5-fluoro-3-methylphenyl)-, 1,1-dimethylethyl ester; 2-(2-Chloro-5-fluoro-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluoro-3-Methylphenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The product is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.