Description

2-Formyl-3-(Morpholino)Phenylboronic Acid Pinacol Ester is a sophisticated bifunctional building block that integrates a formyl group and a protected boronic acid moiety on an aromatic ring, further functionalized with a morpholine substituent. This unique structure makes it a highly valuable intermediate for the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise molecular architecture for creating novel compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other targeted therapies.
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol-protected boronic ester functionality enables efficient palladium-catalyzed cross-coupling to form biaryl structures, a cornerstone of modern medicinal chemistry.
• Ligand and Catalyst Development: Used to create novel bidentate or tridentate ligands for catalysis, leveraging both the boronate and aldehyde groups for complexation.
• Functional Material Synthesis: Serves as a building block for organic electronic materials, such as those used in OLEDs or organic photovoltaics, where the morpholine and formyl groups can tune electronic properties.
• Agrochemical Research: Employed in the discovery and development of new herbicides, fungicides, and plant growth regulators with specific modes of action.
• Chemical Biology Probes: Useful for synthesizing molecular probes and tags for studying biological processes, where the aldehyde can be used for conjugation.

Basic Information

Product Name	2-Formyl-3-(Morpholino)Phenylboronic Acid Pinacol Ester
CAS No.	2121512-13-6
Molecular Formula	C₁₈H₂₆BNO₄
Molecular Weight	331.22 g/mol
Synonyms	3-Formyl-4-Morpholinophenylboronic Acid Pinacol Ester; (3-Formyl-4-Morpholinophenyl)boronic Acid Pinacol Ester; 2-Formyl-3-Morpholinobenzeneboronic Acid Pinacol Ester; 4-(2-Formyl-3-Boronic Acid Pinacol Ester Phenyl)Morpholine; 2-Formyl-3-Morpholinophenylboronic Acid Pinacol Ester; PINACOL [3-FORMYL-4-(MORPHOLIN-4-YL)PHENYL]BORONATE
EINECS	Contact for details

Quality Control

Our 2-Formyl-3-(Morpholino)Phenylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and scale-up applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.