Description

2,5-Difluoro-4-Formylphenylphenylboronic Acid Pinacol Ester is a sophisticated bifunctional organoboron building block, crucial for modern synthetic chemistry. Its value lies in the strategic combination of a protected boronic acid group and a formyl group on a difluorinated aromatic scaffold, enabling precise cross-coupling and subsequent functionalization in a single molecule. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for constructing complex, fluorinated biaryl structures via Suzuki-Miyaura coupling.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for constructing fluorinated biaryl motifs common in drug candidates targeting various diseases.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides where the difluoro and formyl groups contribute to biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or building block for creating novel organic electronic materials, such as fluorinated polymers or small molecules for OLEDs and semiconductors.
• Ligand and Catalyst Development: Employed in the design and synthesis of specialized ligands for catalysis, leveraging the boronic ester for conjugation and the aldehyde for further modification.
• Chemical Biology Probes: Utilized to create tagged molecules or bioconjugates for studying biological processes, where the boronic ester can be used for selective binding or the aldehyde for click chemistry.
• Cross-Coupling Reactions: Primarily designed for use in Suzuki-Miyaura cross-coupling reactions to form carbon-carbon bonds, a cornerstone reaction in medicinal and process chemistry.

Basic Information

Product Name	2,5-Difluoro-4-Formylphenylphenylboronic Acid Pinacol Ester
CAS No.	2121512-03-4
Molecular Formula	C20H21BF2O3
Molecular Weight	358.19 g/mol
Synonyms	[4-Formyl-2,5-difluorophenyl]boronic acid pinacol ester; 2,5-Difluoro-4-formylbenzeneboronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-(2,5-difluoro-4-formylphenyl)-1,3,2-dioxaborolane; (2,5-Difluoro-4-formylphenyl)boronic acid pinacol ester; Pinacol (2,5-difluoro-4-formylphenyl)boronate; Boronic acid, B-(2,5-difluoro-4-formylphenyl)-, 1,1-dimethylethyl ester; Difluoroformylphenylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Every batch of 2,5-Difluoro-4-Formylphenylphenylboronic Acid Pinacol Ester is manufactured and analyzed under strict quality management protocols to ensure consistency and high purity for research and development applications. Our products undergo rigorous quality testing, including HPLC, NMR, and mass spectrometry, to ensure compliance with stringent internal specifications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.