Description

2-Hydroxymethylthiophen-3-Boronic Acid, Pinacol Ester is a high-value, protected boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its primary value lies in its dual functionality, offering both a protected boronic acid group for Suzuki-Miyaura cross-coupling reactions and a hydroxymethyl handle for further derivatization. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries who are developing novel thiophene-containing molecules, such as active pharmaceutical ingredients (APIs) and advanced organic electronic materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex thiophene-based scaffolds in drug discovery and development, particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel crop protection agents and herbicides that incorporate the thiophene heterocycle.
• Material Science Research: Serves as a precursor for conjugated polymers and organic semiconductors used in OLEDs, OFETs, and solar cells.
• Suzuki-Miyaura Cross-Coupling: The pinacol-protected boronic ester group enables efficient, palladium-catalyzed carbon-carbon bond formation with aryl/heteroaryl halides under mild conditions.
• Chemical Derivatization: The hydroxymethyl group allows for further functionalization through esterification, etherification, or oxidation to an aldehyde.
• Ligand and Catalyst Development: Employed in the synthesis of novel thiophene-based ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	2-Hydroxymethylthiophen-3-Boronic Acid, Pinacol Ester
CAS No.	2121511-82-6
Molecular Formula	C11H17BO3S
Molecular Weight	240.13 g/mol
Synonyms	3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-methanol; 2-(Hydroxymethyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene; Thiophene-2-methanol, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 2-Hydroxymethyl-3-thienylboronic acid pinacol ester; (2-(Hydroxymethyl)thiophen-3-yl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-Hydroxymethylthiophen-3-Boronic Acid, Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity and impurity profiles. Our quality management system is designed to meet the stringent requirements of our global customer base in advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.