Description

5-Bromo-2-Isopropoxypyridine-3-Boronic Acid Pinacol Ester is a high-value, organoboron building block essential for modern cross-coupling reactions in pharmaceutical and agrochemical research. Its molecular structure, featuring both a bromine substituent and a protected boronic acid group, makes it a versatile intermediate for constructing complex heterocyclic scaffolds. This compound is primarily utilized by medicinal chemists and process development scientists in the synthesis of active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between aryl/heteroaryl halides and boronic acids, critical for constructing biaryl motifs in drug candidates.
• Pharmaceutical Intermediate: Serves as a crucial building block in the research and development of novel small-molecule therapeutics, particularly kinase inhibitors and central nervous system (CNS) agents.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides that require specific pyridine-based architectures.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as ligands for OLEDs and conductive polymers.
• Chemical Biology Probes: Facilitates the creation of tagged molecules for studying biological pathways and protein interactions.
• Process Chemistry & Scale-up: Provides a reliable, high-purity starting material for optimizing synthetic routes from laboratory to pilot plant scale.

Basic Information

Product Name	5-Bromo-2-Isopropoxypyridine-3-Boronic Acid Pinacol Ester
CAS No.	2121511-77-9
Molecular Formula	C15H21BBrNO3
Molecular Weight	354.05 g/mol
Synonyms	5-Bromo-2-isopropoxy-3-pyridineboronic acid pinacol ester; (5-Bromo-2-isopropoxypyridin-3-yl)boronic acid pinacol ester; 2-Isopropoxy-5-bromopyridine-3-boronic acid pinacol ester; 3-Borono-5-bromo-2-isopropoxypyridine pinacol ester; 5-Bromo-2-(1-methylethoxy)-3-pyridineboronic acid pinacol ester; PINACOL (5-BROMO-2-ISOPROPOXYPYRIDIN-3-YL)BORONATE; 2121511-77-9
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-2-Isopropoxypyridine-3-Boronic Acid Pinacol Ester is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing, including HPLC, NMR, and mass spectrometry, to ensure compliance with industry standards and customer specifications for research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.