Description

2,6-Difluoro-3-Hydroxymethylphenylboronic Acid Pinacol Ester is a high-value, multifunctional organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially in fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced, fluorinated herbicides, fungicides, and insecticides to enhance efficacy and environmental profile.
• Ligand & Catalyst Development: Serves as a precursor for creating novel bidentate ligands and organometallic catalysts for asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated organic semiconductors, liquid crystals, and polymers for electronic and optoelectronic devices.
• Chemical Biology Probes: Utilized to create tagged molecules and bioconjugates for studying biological pathways and target engagement.
• Scale-up Process Chemistry: Suitable for transition from laboratory-scale discovery to pilot plant and commercial manufacturing due to its stability.

Basic Information

Product Name	2,6-Difluoro-3-Hydroxymethylphenylboronic Acid Pinacol Ester
CAS No.	2121511-74-6
Molecular Formula	C₁₄H₁₉BF₂O₃
Molecular Weight	284.11 g/mol
Synonyms	2,6-Difluoro-3-(hydroxymethyl)phenylboronic acid pinacol ester; (2,6-Difluoro-3-(hydroxymethyl)phenyl)boronic acid pinacol ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(hydroxymethyl)-1,2-difluorobenzene; 2,6-Difluoro-3-(hydroxymethyl)benzeneboronic acid pinacol ester; Boronic acid, B-[2,6-difluoro-3-(hydroxymethyl)phenyl]-, 1,1-dimethylethyl ester; CAS 2121511-74-6; 2,6-Difluoro-3-hydroxymethylphenyl-Bpin
EINECS	Contact for details

Quality Control

Our 2,6-Difluoro-3-Hydroxymethylphenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistency suitable for demanding R&D and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere (argon or nitrogen) in a desiccator to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.