Description

5-Chloro-2-Isopropoxypyridine-3-Boronic Acid Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry, particularly in cross-coupling reactions. Its primary value lies in serving as a critical, stable building block for constructing complex molecular architectures in pharmaceutical and agrochemical research. This compound is specifically needed by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), advanced materials, and novel crop protection agents.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between aryl/heteroaryl halides and boronic acids, enabling the synthesis of complex biaryl and heterobiaryl structures.
• Pharmaceutical Intermediate: Used in the research and development of novel drug candidates, particularly those containing functionalized pyridine cores, such as kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Serves as a building block for creating advanced herbicides, fungicides, and insecticides with tailored properties.
• Material Science Research: Employed in the synthesis of organic electronic materials, ligands for catalysts, and metal-organic frameworks (MOFs).
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Utilized as a linker or functional component in the design of bifunctional molecules for targeted protein degradation.
• Scale-up and Process Chemistry: The pinacol ester protection enhances stability, making it suitable for multi-step synthesis and larger-scale manufacturing processes.

Basic Information

Product Name	5-Chloro-2-Isopropoxypyridine-3-Boronic Acid Pinacol Ester
CAS No.	2121511-57-5
Molecular Formula	C14H21BClNO3
Molecular Weight	297.58 g/mol
Synonyms	5-Chloro-2-isopropoxy-3-pyridineboronic acid pinacol ester; (5-Chloro-2-isopropoxypyridin-3-yl)boronic acid pinacol ester; 2-Isopropoxy-5-chloropyridine-3-boronic acid pinacol ester; 3-Boronic acid, 5-chloro-2-(1-methylethoxy)-, pinacol ester, pyridine; 5-Chloro-2-(propan-2-yloxy)pyridine-3-boronic acid pinacol ester; Boronic acid, B-[5-chloro-2-(1-methylethoxy)-3-pyridinyl]-, pinacol ester
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Isopropoxypyridine-3-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Products undergo rigorous analytical testing, including HPLC, NMR, and LC-MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each batch to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.