Description

Ald-Ph-Peg3-o-Nh-Boc is a specialized bifunctional PEG linker featuring a terminal aldehyde group and a Boc-protected amine, designed for advanced bioconjugation and chemical synthesis. This compound is critical for creating stable, site-specific linkages in the development of antibody-drug conjugates (ADCs), peptide therapeutics, and diagnostic probes. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity, functionalized linkers for precision chemistry.

Application

• Antibody-Drug Conjugate (ADC) Development: As a key linker for connecting cytotoxic payloads to monoclonal antibodies via its reactive aldehyde and amine groups.
• Peptide and Protein Modification: For site-specific PEGylation to enhance the solubility, stability, and pharmacokinetic profiles of therapeutic peptides and proteins.
• Biomolecule Immobilization: Used to functionalize surfaces, nanoparticles, or resins for biosensor development, diagnostic assays, and affinity chromatography.
• Cross-linking Agent: Employed in the synthesis of complex polymer-drug conjugates and hydrogel networks for controlled drug delivery systems.
• Organic Synthesis Intermediate: Serves as a versatile building block in medicinal chemistry for constructing complex molecules with tailored spacer arms.

Basic Information

Product Name	Ald-Ph-Peg3-o-Nh-Boc
CAS No.	2110449-01-7
Molecular Formula	C22H35NO8
Molecular Weight	441.52 g/mol
Synonyms	1-Boc-3,6,9-trioxa-12-azatetradecan-14-al; 4,7,10-Trioxa-13-azapentadecan-15-oic acid, 14-oxo-, 1,1-dimethylethyl ester; Ald-Ph-PEG3-NH-Boc; Boc-NH-PEG3-CHO; (Boc-amino)-PEG3-aldehyde; tert-Butyl (14-oxo-4,7,10-trioxa-13-azapentadecan-15-yl)carbamate; Fmoc-PEG3-aldehyde precursor; Amino-PEG3-aldehyde Boc-protected
EINECS	Contact for details

Quality Control

Our Ald-Ph-Peg3-o-Nh-Boc is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and NMR for structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to relevant industry standards to support our customers in research, development, and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and degradation. Allow the sealed container to reach room temperature before opening to minimize moisture absorption. For long-term storage, desiccate the container.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.