Description

Boc-5-Methoxy-Dl-Tryptophan is a protected derivative of the non-proteinogenic amino acid tryptophan, featuring a tert-butoxycarbonyl (Boc) protecting group on the amine and a methoxy substituent on the indole ring. This compound is a critical building block in peptide synthesis and medicinal chemistry research, offering enhanced stability and controlled reactivity for the construction of complex molecules. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on developing novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Peptide Synthesis Intermediate: Serves as a key protected amino acid residue in solid-phase and solution-phase peptide synthesis (SPPS) for introducing modified tryptophan analogs.
• Pharmaceutical Research & Development: Used as a building block in the discovery and development of new drug candidates, particularly in oncology, neurology, and metabolic disease research.
• Bioconjugation & Probe Development: Facilitates the site-specific incorporation of a fluorescent or reactive handle into peptides and proteins for biochemical assays and imaging studies.
• Academic & Institutional Research: Employed in university and institutional labs for fundamental studies in organic chemistry, chemical biology, and peptide structure-activity relationships (SAR).
• Process Chemistry & Scale-Up: Acts as a starting material or intermediate in the pilot-scale and commercial-scale production of specialized peptide-based active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Boc-5-Methoxy-Dl-Tryptophan
CAS No.	2103356-55-2
Molecular Formula	C₁₉H₂₄N₂O₅
Molecular Weight	360.41 g/mol
Synonyms	N-α-Boc-5-Methoxy-DL-tryptophan; (RS)-2-[(tert-Butoxycarbonyl)amino]-3-(5-methoxy-1H-indol-3-yl)propanoic acid; Boc-5-MeO-DL-Trp-OH; 5-Methoxy-DL-tryptophan, N-Boc-; tert-Butyl (RS)-1-[(5-methoxy-1H-indol-3-yl)methyl]-2-oxo-2-ethoxycarbonylaminoethylcarbamate (related); BOC-5-METHOXY-DL-TRYPTOPHAN; DL-5-Methoxytryptophan, N-BOC-
EINECS	Contact for details

Quality Control

Our Boc-5-Methoxy-Dl-Tryptophan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and chiral analysis to verify the racemic mixture. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or production specifications. We support cGMP standards for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.5%
Chiral Purity (DL Ratio)	~50:50 (Racemic)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.