Description

Ald-Ph-Peg2-T-Butyl Ester CAS NO 2100306-65-6 is a specialized bifunctional PEG derivative featuring a terminal aldehyde group and a tert-butyl ester-protected carboxylic acid. This compound is engineered to serve as a versatile heterobifunctional linker for the controlled conjugation of biomolecules, enabling precise control over cross-linking reactions. It is a critical reagent for researchers and manufacturers in the pharmaceutical and bioconjugation sectors who require high-purity intermediates for developing antibody-drug conjugates (ADCs), peptide modifications, and advanced polymer therapeutics.

Application

• As a key heterobifunctional linker in the synthesis of Antibody-Drug Conjugates (ADCs) and other targeted therapeutics.
• For the site-specific modification and functionalization of peptides, proteins, and oligonucleotides.
• In the development of PEGylated drug delivery systems to enhance solubility and pharmacokinetic profiles.
• As a building block for synthesizing complex, multi-arm PEG derivatives and functionalized polymers.
• In bioconjugation research for attaching payloads, labels, or surfaces via orthogonal reactive groups (aldehyde and activated ester).
• For the preparation of diagnostic reagents and biosensors requiring controlled immobilization chemistry.

Basic Information

Product Name	Ald-Ph-Peg2-T-Butyl Ester
CAS No.	2100306-65-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	4-Formylbenzyl-PEG2-T-butyl ester; 4-Formylbenzyl-PEG2-t-butyl ester; Ald-Ph-PEG2-tBu ester; Benzaldehyde, 4-[[2-[2-[(1,1-Dimethylethoxy)carbonyl]ethoxy]ethoxy]methyl]-; T-butyl 3,6-dioxa-8-((4-formylbenzyl)oxy)octanoate; Heterobifunctional PEG linker aldehyde/t-butyl ester; Fmoc-PEG2-CH2-CH2-tBu ester (precursor); Alkyne-PEG2-t-butyl ester (related analog)
EINECS	Contact for details

Quality Control

Our Ald-Ph-Peg2-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your GMP and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and hydrolysis. Keep the container in a cool, dry, well-ventilated area away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or oil
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.