Description

n-(Boc-Peg1)-n-Bis(Peg2-Propargyl) is a specialized heterobifunctional polyethylene glycol (PEG) derivative designed for advanced bioconjugation and materials science applications. This compound is engineered to provide orthogonal reactivity, featuring a tert-butoxycarbonyl (Boc)-protected amine for controlled deprotection and two propargyl-terminated PEG arms for copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry. It is an essential building block for researchers and manufacturers in pharmaceutical development, proteomics, and polymer chemistry who require precise, high-purity linkers to create complex molecular architectures.

Application

• ADC (Antibody-Drug Conjugate) Linker Synthesis: Serves as a key intermediate for constructing cleavable or non-cleavable linkers with controlled drug-to-antibody ratios (DAR).
• PEGylation Reagent: Used to modify peptides, proteins, and oligonucleotides to enhance solubility, stability, and pharmacokinetic profiles.
• Dendrimer and Star Polymer Synthesis: Acts as a core molecule for building multi-arm, functionalized polymeric structures via click chemistry.
• Surface Functionalization: Enables the covalent attachment of biomolecules or catalysts to nanoparticles, biosensors, and microarray slides.
• Cross-linking Agent: Facilitates the formation of hydrogels and polymer networks with tailored mechanical and chemical properties.
• Chemical Probe Development: Utilized in creating tools for activity-based protein profiling (ABPP) and diagnostic assays.

Basic Information

Product Name	n-(Boc-Peg1)-n-Bis(Peg2-Propargyl)
CAS No.	2100306-63-4
Molecular Formula	C22H38N2O8
Molecular Weight	458.55 g/mol
Synonyms	1-Boc-1,4,7-trioxa-10-azadodecane-12,12-diyl bis(2-methyl-2-propynyl) ether; tert-Butyl (8,11-dioxa-2-aza-14,14-di(prop-2-yn-1-yloxy)tetradecyl)carbamate; Boc-NH-PEG1-N-bis(PEG2-propargyl); Boc-Amine-PEG1-bis(PEG2-Alkyne); Heterobifunctional PEG Alkyne Linker; Boc-protected PEG bis-propargyl ether
EINECS	Contact for details

Quality Control

Our n-(Boc-Peg1)-n-Bis(Peg2-Propargyl) is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity for sensitive research and production applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional group integrity. We adhere to cGMP guidelines where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical development and advanced material synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.