Description

2-Ethyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenol is a high-value, advanced pharmaceutical intermediate and building block featuring a protected boronic ester group. This compound matters for its critical role in modern synthetic chemistry, specifically in Suzuki-Miyaura cross-coupling reactions, which are fundamental for constructing complex molecules in drug discovery and materials science. It is essential for R&D chemists and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require the introduction of specific phenolic and boron-containing motifs.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the creation of advanced polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura cross-coupling to form biaryl and heterobiaryl carbon-carbon bonds with high efficiency and selectivity.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for exploring new synthetic pathways and creating compound libraries for screening.
• Protecting Group Strategy: The pinacol boronic ester group acts as a protected form of boronic acid, offering improved stability and handling for multi-step syntheses.

Basic Information

Product Name	2-Ethyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenol
CAS No.	2098426-15-2
Molecular Formula	C14H21BO3
Molecular Weight	248.13 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-ethylphenol; 2-Ethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol; 2-Ethyl-4-pinacolatoborylphenol; 4-Pinacolatoboranyl-2-ethylphenol; Phenol, 2-ethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 2-Ethyl-4-boronic acid pinacol ester phenol
EINECS	Contact for details

Quality Control

Our production of 2-Ethyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenol adheres to stringent quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original packaging to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.