Description

2-Cyclopropylpyridine-3-Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a critical step in constructing complex molecules for drug discovery and material science. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce the cyclopropylpyridine moiety into target structures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require the cyclopropylpyridine scaffold.
• Material Science Research: Serves as a precursor for creating functionalized organic materials, ligands for catalysis, and components for organic electronic devices.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronic ester group makes it a stable and highly reactive partner for palladium-catalyzed coupling with various aryl and heteroaryl halides.
• Library Synthesis for Drug Discovery: Enables the rapid, parallel synthesis of diverse compound libraries for high-throughput screening in medicinal chemistry programs.
• Chemical Biology Probes: Used to create labeled molecules or probes for studying biological pathways and target engagement.

Basic Information

Product Name	2-Cyclopropylpyridine-3-Boronic Acid Pinacol Ester
CAS No.	2098215-65-5
Molecular Formula	C14H18BNO2
Molecular Weight	243.11 g/mol
Synonyms	2-Cyclopropyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-cyclopropylpyridine; 2-Cyclopropyl-3-pyridineboronic acid pinacol ester; 2-Cyclopropylpyridin-3-ylboronic acid pinacol ester; Boronic acid, B-(2-cyclopropyl-3-pyridinyl)-, 1,1-dimethylethyl ester; 2-Cyclopropyl-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
EINECS	Contact for details

Quality Control

Our 2-Cyclopropylpyridine-3-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive coupling reactions. All materials are fully characterized (NMR, HPLC, MS) and undergo rigorous purity analysis. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with each shipment, supporting compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry, well-ventilated place. This compound is easily oxidized; prolonged exposure to air or moisture should be avoided. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.