Description

2,2-Difluoro-3-(2-Fluorophenyl)Cyclopropane-1-Carboxylic Acid is a high-value, multi-fluorinated cyclopropane carboxylic acid derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its unique difluorocyclopropane scaffold fused with a fluorinated aromatic ring makes it an essential building block for constructing complex molecules with tailored physicochemical properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where the introduction of fluorine atoms is a key strategy to modulate bioactivity, metabolic stability, and membrane permeability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluorocyclopropane moiety can enhance biological activity and environmental profile.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the synthesis of specialty polymers and advanced materials with specific dielectric or surface properties.
• Fluorine Chemistry & Catalysis: A valuable substrate in methodological studies for developing new fluorination reactions and asymmetric catalysis.
• Ligand and Probe Synthesis: Utilized in creating complex ligands for catalysis or fluorescent molecular probes for biochemical imaging and diagnostics.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical companies for use in custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	2,2-Difluoro-3-(2-Fluorophenyl)Cyclopropane-1-Carboxylic Acid
CAS No.	2098054-07-8
Molecular Formula	C10H7F3O2
Molecular Weight	216.16 g/mol
Synonyms	2,2-Difluoro-3-(2-fluorophenyl)cyclopropanecarboxylic acid; 2-Fluorophenyl-2,2-difluorocyclopropanecarboxylic Acid; 1-Carboxy-2,2-difluoro-3-(2-fluorophenyl)cyclopropane; (1R,3S)-2,2-Difluoro-3-(2-fluorophenyl)cyclopropane-1-carboxylic acid (for stereoisomer); (1S,3R)-2,2-Difluoro-3-(2-fluorophenyl)cyclopropane-1-carboxylic acid (for stereoisomer); DFPC Acid; 2-Fluoro-α-(2,2-difluorocyclopropyl)benzoic Acid
EINECS	Contact for details

Quality Control

Our production of 2,2-Difluoro-3-(2-Fluorophenyl)Cyclopropane-1-Carboxylic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets exacting customer specifications. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment. Our facilities operate under cGMP principles where applicable, ensuring consistent quality, batch-to-batch reproducibility, and reliable supply for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation due to moisture absorption. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm
Specific Rotation (if chiral)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.