Description

(1R,4R)-4-(Difluoromethyl)Cyclohexan-1-Amine Hydrochloride, Trans is a high-purity, stereochemically defined chiral amine hydrochloride salt. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecules with specific three-dimensional configurations.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced, enantiomerically pure herbicides, fungicides, and insecticides for enhanced efficacy.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Fine Chemical Building Block: Employed in custom synthesis and contract manufacturing for specialty chemicals requiring the trans-cyclohexylamine scaffold.
• Academic & Industrial Research: A valuable reagent for methodological studies in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	(1R,4R)-4-(Difluoromethyl)Cyclohexan-1-Amine Hydrochloride, Trans
CAS No.	2098033-30-6
Molecular Formula	C7H14ClF2N
Molecular Weight	185.64 g/mol
Synonyms	trans-4-(Difluoromethyl)cyclohexanamine hydrochloride; (1R,4R)-4-(Difluoromethyl)cyclohexan-1-amine HCl; (1R,4R)-4-(Difluoromethyl)-1-aminocyclohexane hydrochloride; trans-4-(Difluoromethyl)-1-aminocyclohexane hydrochloride; (1R,4R)-rel-4-(Difluoromethyl)cyclohexanamine hydrochloride; (1R,4R)-4-(Difluoromethyl)cyclohexylamine hydrochloride; (1R,4R)-Amino-4-(difluoromethyl)cyclohexane hydrochloride
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We offer material with typical purities exceeding 98% (HPLC) and can provide custom grades to meet specific project requirements. Comprehensive analytical characterization, including chiral purity confirmation by HPLC, is performed. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de (trans isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.