Description

5-Thiazolecarboxamide, n-[(2S)-2-(4-Chlorophenyl)-2-(4-Morpholinyl)Ethyl]-2-(2-Pyrimidinyl)-4-(Trifluoromethyl)- is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound matters for its role as a critical building block in the synthesis of novel, targeted therapeutic agents, offering researchers precise molecular control. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing next-generation drugs, particularly in oncology and other specialized therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the research and development of new active pharmaceutical ingredients (APIs), especially for targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Oncology Drug Development: Serves as a specialized scaffold for synthesizing potential kinase inhibitors and other anti-cancer compounds.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target validation.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke, multi-step synthetic routes.
• Process Chemistry Scale-up: Acts as a critical intermediate during the optimization and scale-up of synthetic routes from lab to pilot plant.

Basic Information

Product Name	5-Thiazolecarboxamide, n-[(2S)-2-(4-Chlorophenyl)-2-(4-Morpholinyl)Ethyl]-2-(2-Pyrimidinyl)-4-(Trifluoromethyl)-
CAS No.	2097117-06-9
Molecular Formula	C22H21ClF3N5O2S
Molecular Weight	511.95 g/mol
Synonyms	N-[(2S)-2-(4-Chlorophenyl)-2-(4-Morpholinyl)Ethyl]-2-(2-Pyrimidinyl)-4-(Trifluoromethyl)-5-Thiazolecarboxamide; (S)-N-(2-(4-Chlorophenyl)-2-Morpholinoethyl)-2-(Pyrimidin-2-yl)-4-(Trifluoromethyl)Thiazole-5-Carboxamide; 2097117-06-9; UNII-6K8K0F2W9F; 6K8K0F2W9F; CHEMBL3186662; Thiazolecarboxamide derivative; Chiral Morpholine-Thiazole Intermediate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing all critical quality attributes are available upon request. We adhere to a quality management system suitable for supplying materials for research and development under current Good Manufacturing Practice (cGMP) principles where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.