Description

1-(4-Nitrophenyl)-3-[3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Urea is a high-purity, advanced pharmaceutical intermediate featuring a unique urea core linked to both a nitrophenyl group and a protected boronic acid ester moiety. This compound is critical for researchers and manufacturers developing novel small-molecule therapeutics, particularly in targeted drug discovery programs. It serves as a key building block for medicinal chemists in the synthesis of potential kinase inhibitors and other bioactive molecules, where its structural elements allow for precise molecular modifications and subsequent Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A crucial precursor in the research and development of new active pharmaceutical ingredients (APIs), especially for targeted cancer therapies.
• Medicinal Chemistry Research: Used as a versatile building block in structure-activity relationship (SAR) studies and lead optimization for drug discovery projects.
• Protease & Kinase Inhibitor Synthesis: Employed in the synthesis of potential inhibitors for various enzymes, leveraging its urea pharmacophore and boronic ester handle.
• Bioconjugation & Probe Development: The boronic ester functionality can be utilized for the development of chemical probes and bioconjugates for diagnostic or therapeutic purposes.
• Organic Synthesis & Material Science: Serves as a specialized monomer or linker in the synthesis of complex organic molecules and advanced functional materials.

Basic Information

Product Name	1-(4-Nitrophenyl)-3-[3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Urea
CAS No.	2096998-08-0
Molecular Formula	C19H22BN3O5
Molecular Weight	383.21 g/mol
Synonyms	3-(4-Nitrophenyl)-1-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; 1-(4-Nitrophenyl)-3-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; Urea, N-(4-nitrophenyl)-N'-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; 2096998-08-0; B-3-(3-(4-Nitrophenyl)ureido)phenylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our production of 1-(4-Nitrophenyl)-3-[3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Urea adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity and identity are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.