Description

3-Bromo-2-Methoxyphenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron building block. This compound is essential for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern pharmaceutical and agrochemical research. It is primarily utilized by R&D chemists and process development scientists in the life sciences sector for constructing complex biaryl and heterobiaryl scaffolds. The pinacol ester group provides enhanced stability, making it a reliable reagent for demanding synthetic sequences.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing substituted biphenyl or heteroaryl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific halogenated aryl structures.
• Material Science Research: Employed in the creation of organic electronic materials, such as ligands for OLEDs or conductive polymers, where precise molecular architecture is critical.
• Chemical Biology & Probe Development: Serves as a versatile handle for bioconjugation and the synthesis of molecular probes for diagnostic and biochemical research applications.
• Academic & Contract Research: A staple reagent in university laboratories and CROs (Contract Research Organizations) for methodology development and complex molecule synthesis.

Basic Information

Product Name	3-Bromo-2-Methoxyphenylboronic Acid Pinacol Ester
CAS No.	2096997-23-6
Molecular Formula	C₁₃H₁₈BBrO₃
Molecular Weight	313.00 g/mol
Synonyms	2-Bromo-6-methoxyphenylboronic acid pinacol ester; (3-Bromo-2-methoxyphenyl)boronic acid pinacol ester; 3-Bromo-2-methoxybenzeneboronic acid pinacol ester; B-(3-Bromo-2-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-(3-bromo-2-methoxyphenyl)-1,3,2-dioxaborolane; 3-Bromo-2-methoxy phenylboronic acid pinacol ester; Boronic acid, B-(3-bromo-2-methoxyphenyl)-, 1,1-dimethylethyl ester (9CI)
EINECS	Contact for details

Quality Control

Our 3-Bromo-2-Methoxyphenylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive coupling reactions. Each lot is analyzed via NMR, HPLC, and GC to confirm identity and purity, with residual solvent levels controlled to ICH guidelines. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C under an inert atmosphere. This material is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.