Description

1-(2,5-Dimethoxyphenyl)-3-[3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Urea is a high-value, functionalized urea derivative containing a boronic ester pinacol group, making it a critical intermediate in modern synthetic chemistry. This compound matters for its dual functionality, serving as a versatile building block for constructing complex molecules via Suzuki-Miyaura cross-coupling reactions and other boron-mediated transformations. Pharmaceutical, agrochemical, and advanced materials researchers need this chemical for developing new active ingredients, functional polymers, and chemical probes, where precise molecular architecture is paramount.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly in kinase inhibitor and protease inhibitor research.
• Agrochemical Development: Used to create new active ingredients for crop protection products through structure-activity relationship (SAR) studies.
• Material Science: Serves as a monomer or cross-linking agent in the development of boron-containing polymers and advanced organic frameworks.
• Chemical Biology & Proteomics: Utilized in the design of activity-based probes (ABPs) and affinity reagents targeting specific enzymes or proteins.
• Suzuki-Miyaura Cross-Coupling: The tetramethyl-1,3,2-dioxaborolan-2-yl (pinacol boronic ester) group enables efficient palladium-catalyzed carbon-carbon bond formation.
• Library Synthesis: A valuable scaffold for generating diverse compound libraries in high-throughput screening for drug discovery.

Basic Information

Product Name	1-(2,5-Dimethoxyphenyl)-3-[3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Urea
CAS No.	2096997-11-2
Molecular Formula	C21H27BN2O5
Molecular Weight	398.26 g/mol
Synonyms	3-(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1-(2,5-dimethoxyphenyl)urea; 1-(2,5-Dimethoxyphenyl)-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea; Urea, N-(2,5-dimethoxyphenyl)-N'-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; Boric acid, cyclic ester with N-(2,5-dimethoxyphenyl)-N'-(3-hydroxyphenyl)urea; Boronic ester urea derivative CAS 2096997-11-2
EINECS	Contact for details

Quality Control

Our production of 1-(2,5-Dimethoxyphenyl)-3-[3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Urea adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and LC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.