Description

1-(4-Methoxy-2-Methylphenyl)-3-[3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Urea is a specialized boronic ester-protected urea derivative, a key intermediate in modern pharmaceutical and agrochemical research. Its value lies in its dual functionality, combining a urea pharmacophore with a protected boronic acid group, enabling its use in Suzuki-Miyaura cross-coupling reactions for constructing complex biaryl structures. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity building blocks for drug discovery and synthesis.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing biaryl motifs for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides where the urea moiety and boronic ester functionality contribute to biological activity.
• Suzuki-Miyaura Cross-Coupling Reactions: The tetramethyl-1,3,2-dioxaborolan-2-yl (pinacol boronic ester) group makes it a stable, air-tolerant reagent for palladium-catalyzed cross-coupling to form carbon-carbon bonds.
• Chemical Biology & Proteomics: Potential use as a molecular probe or in the development of boronic acid-based sensors and inhibitors that target serine proteases or carbohydrate-binding proteins.
• Material Science Precursor: Can be utilized in the synthesis of organic electronic materials, such as polymers or small molecules for OLEDs or OFETs, where precise molecular architecture is required.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific, high-value boronic ester intermediates.

Basic Information

Product Name	1-(4-Methoxy-2-Methylphenyl)-3-[3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Urea
CAS No.	2096997-05-4
Molecular Formula	C21H27BN2O4
Molecular Weight	382.26 g/mol
Synonyms	3-(4-Methoxy-2-methylphenyl)-1-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; 1-(4-Methoxy-2-methylphenyl)-3-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; Urea, N-(4-methoxy-2-methylphenyl)-N'-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; B-[3-[[(4-Methoxy-2-methylphenyl)amino]carbonyl]amino]phenyl]boronic acid pinacol ester; 3-(Pinacolboryl)phenyl-(4-methoxy-2-methylphenyl)urea
EINECS	Contact for details

Quality Control

Our 1-(4-Methoxy-2-Methylphenyl)-3-[3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Urea is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR (1H, 13C, 11B) for structural confirmation, and mass spectrometry to ensure identity and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic and easily oxidized nature, it is recommended to store the product under an inert atmosphere (argon or nitrogen) for long-term preservation. Keep the container tightly sealed in a desiccator to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.