Description

tert-Butyl 6-Chloro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Picolinate is a high-value, organoboron building block essential for modern synthetic chemistry. This compound matters because it serves as a key intermediate in the Suzuki-Miyaura cross-coupling reaction, enabling the efficient construction of complex biaryl structures. Pharmaceutical, agrochemical, and advanced materials researchers need it for the development of new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Critical for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly in constructing substituted picolinate and biphenyl scaffolds.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific halogenated and boronic ester functionalities.
• Material Science Research: Employed in the creation of organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or monomers for conjugated polymers.
• Cross-Coupling Reactions: Primarily utilized as a boronic ester reagent in palladium-catalyzed Suzuki-Miyaura cross-coupling to form carbon-carbon bonds under mild conditions.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the synthesis of molecular probes and tags.
• Academic & Contract Research: Serves as a specialized reagent for methodology development and complex molecule synthesis in research laboratories.

Basic Information

Product Name	tert-Butyl 6-Chloro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Picolinate
CAS No.	2096341-89-6
Molecular Formula	C16H23BClNO4
Molecular Weight	339.62 g/mol
Synonyms	6-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinic acid tert-butyl ester; tert-Butyl 6-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-carboxylate; 2-Picolinic acid, 6-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester; Pinacol 6-Chloro-4-boronate picolinate tert-butyl ester; 6-Chloro-4-Bpin picolinic acid tert-butyl ester (where Bpin = 4,4,5,5-tetramethyl-1,3,2-dioxaborolanyl); Boronic acid, B-[6-chloro-4-[(1,1-dimethylethoxy)carbonyl]-2-pyridinyl]-, pinacol ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Chloro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Picolinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for critical coupling reactions. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) and handle it in a moisture-controlled environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.