Description

1-(3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperidine is a high-value, organoboron building block designed for advanced pharmaceutical and agrochemical research. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a critical step for constructing complex carbon-carbon bonds in target molecules. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical industry, particularly for synthesizing novel drug candidates and fine chemicals. Its specific structure offers a strategic handle for introducing the piperidine moiety into complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially in central nervous system (CNS) and oncology research.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester reagent for palladium-catalyzed coupling with aryl/heteroaryl halides to form biaryl structures.
• Medicinal Chemistry: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Agrochemical Synthesis: Intermediate in the development of novel herbicides, fungicides, and insecticides requiring specific fluorinated and heterocyclic motifs.
• Material Science Research: Potential precursor for organic electronic materials and ligands in catalytic systems.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up services.

Basic Information

Product Name	1-(3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperidine
CAS No.	2096341-85-2
Molecular Formula	C18H27BFNO2
Molecular Weight	319.23 g/mol
Synonyms	1-[(3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methyl]piperidine; 2-[2-Fluoro-4-(piperidin-1-ylmethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1-(3-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Piperidine; Piperidine, 1-[[3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl]-; (3-Fluoro-4-(piperidin-1-ylmethyl)phenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 1-(3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates for research and development under cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when appropriate to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.