Description

1-{[2-Chloro-6-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl}Pyrrolidine is a high-value, advanced pharmaceutical intermediate featuring a unique boronic ester-protected structure. This compound is critical for enabling efficient cross-coupling reactions, particularly in the synthesis of complex, biologically active molecules. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boron-containing coupling partner for the synthesis of biaryl structures, a common motif in drug discovery.
• Pharmaceutical Intermediate: Used in the research and development of novel therapeutic agents, including kinase inhibitors and other small molecule drugs.
• Agrochemical Synthesis: Employed in the creation of advanced crop protection agents and herbicides.
• Material Science Research: Acts as a building block for organic electronic materials and functional polymers.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways.
• Process Chemistry & Scale-up: Provides a stable, handleable boronate source for optimizing manufacturing routes for target compounds.

Basic Information

Product Name	1-{[2-Chloro-6-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl}Pyrrolidine
CAS No.	2096341-78-3
Molecular Formula	C17H25BClNO2
Molecular Weight	321.65 g/mol
Synonyms	2-Chloro-6-((pyrrolidin-1-yl)methyl)phenylboronic acid pinacol ester; (2-Chloro-6-((pyrrolidin-1-yl)methyl)phenyl)boronic acid pinacol ester; 1-((2-Chloro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methyl)pyrrolidine; 2-(2-Chloro-6-(pyrrolidin-1-ylmethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; B-(2-Chloro-6-((pyrrolidin-1-yl)methyl)phenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 1-{[2-Chloro-6-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl}Pyrrolidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.