Description

1-{[2-Chloro-6-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl}-4-Methylpiperazine is a high-value, advanced pharmaceutical intermediate featuring a boronic ester-protected pinacol group. This compound is critical for enabling efficient cross-coupling reactions, particularly in the synthesis of complex small molecule APIs. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel chemical entities.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boron-containing coupling partner for constructing biaryl and heterobiaryl scaffolds in drug discovery.
• Pharmaceutical Intermediate: Used in the research and development of potential therapeutic agents, including kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Employed in the creation of novel active ingredients for crop protection products.
• Material Science Research: Acts as a building block for organic electronic materials and functional polymers.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and probes for studying biological pathways.
• Process Chemistry Development: Provides a stable, crystalline boronate source for scalable manufacturing routes.

Basic Information

Product Name	1-{[2-Chloro-6-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl}-4-Methylpiperazine
CAS No.	2096340-35-9
Molecular Formula	C18H28BClN2O2
Molecular Weight	350.69 g/mol
Synonyms	2-Chloro-6-((4-methylpiperazin-1-yl)methyl)phenylboronic acid pinacol ester; (2-Chloro-6-((4-methylpiperazin-1-yl)methyl)phenyl)boronic acid pinacol ester; 1-((2-Chloro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)-4-methylpiperazine; 2096340-35-9; 1-[(2-Chloro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methyl]-4-methylpiperazine
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and LC-MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed in a dry environment to prevent moisture uptake, which can affect stability and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.