Description

2-Amino-5-Chloropyridine-3-Boronic Acid Pinacol Ester is a high-value, multi-functional organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, to construct complex heterocyclic scaffolds. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the discovery and synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with complex pyridine-based structures.
• Material Science Research: Serves as a precursor for creating functionalized polymers, ligands for catalysts, and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: The pinacol ester group protects the boronic acid, enhancing stability and handling for efficient C-C bond formation with aryl/heteroaryl halides.
• Library Synthesis for Drug Discovery: Enables the rapid generation of diverse compound libraries for high-throughput screening in medicinal chemistry programs.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes to study biological pathways and protein functions.

Basic Information

Item	Detail
Product Name	2-Amino-5-Chloropyridine-3-Boronic Acid Pinacol Ester
CAS No.	2096339-55-6
Molecular Formula	C11H16BClN2O2
Molecular Weight	254.52 g/mol
Synonyms	(2-Amino-5-chloropyridin-3-yl)boronic acid pinacol ester; 5-Chloro-2-aminopyridine-3-boronic acid pinacol ester; 2-Amino-5-chloro-3-pyridineboronic acid pinacol ester; 3-Boronic acid, 2-amino-5-chloropyridine, pinacol ester; 2-Amino-5-chloro-3-pyridinylboronic acid pinacol ester; 5-Chloro-2-aminopyridin-3-ylboronic acid pinacol ester; PINACOL 2-AMINO-5-CHLOROPYRIDINE-3-BORONATE
EINECS	Contact for details

Quality Control

Every batch of our 2-Amino-5-Chloropyridine-3-Boronic Acid Pinacol Ester undergoes rigorous analytical testing to ensure high purity and consistency suitable for research and development applications. We employ advanced techniques including HPLC, NMR (1H, 13C, 11B), and mass spectrometry for comprehensive characterization. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C to minimize oxidation and hydrolysis. Due to its hygroscopic nature, the container should be allowed to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.