Description

2-(3-(Azidomethyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-value, multifunctional organic building block that combines a phenylazidomethyl group with a pinacol boronate ester. This compound matters for its critical role as a versatile intermediate in modern synthetic chemistry, enabling efficient cross-coupling and click chemistry reactions. It is primarily needed by pharmaceutical R&D teams, agrochemical manufacturers, and advanced materials scientists for constructing complex molecular architectures, including potential active pharmaceutical ingredients (APIs) and functional polymers.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for the synthesis of novel biaryl compounds targeted in drug discovery programs.
• Peptide & Protein Modification: Utilized in bio-conjugation strategies via copper-catalyzed azide-alkyne cycloaddition (CuAAC) "click" chemistry to attach functional moieties.
• Polymer & Materials Science: Serves as a monomer or functionalization agent for creating advanced polymers with tailored properties, such as stimuli-responsive materials.
• Agrochemical Synthesis: Employed in the development of new crop protection agents and herbicides that require specific boronic acid derivatives.
• Chemical Biology Probes: Used to create labeled molecules and probes for studying biological processes and target engagement.
• Ligand & Catalyst Development: Acts as a starting material for synthesizing novel ligands and organometallic catalysts.

Basic Information

Item	Details
Product Name	2-(3-(Azidomethyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	2096338-71-3
Molecular Formula	C14H20BN3O2
Molecular Weight	273.14 g/mol
Synonyms	3-(Azidomethyl)phenylboronic acid pinacol ester; (3-(Azidomethyl)phenyl)boronic acid pinacol ester; 1-Azido-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methylbenzene; 2-[3-(Azidomethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-(Azidomethyl)benzeneboronic acid pinacol ester; Azido-Phe-Bpin; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 2-(3-(Azidomethyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure high purity and batch-to-batch consistency suitable for research and scale-up applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C/59-77°F). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.