Description

2-Chloro-5-Methoxypyridine-4-Boronic Acid Pinacol Ester is a high-value, protected boronic acid derivative crucial for modern synthetic chemistry. This compound serves as a key building block in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in kinase inhibitor and CNS-active compound research.
• Agrochemical Synthesis: Used to construct complex heterocyclic scaffolds found in advanced herbicides, fungicides, and insecticides.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and organic semiconductors, due to its pyridine-based structure.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in homogeneous catalysis.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological processes.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs and fine chemical companies for custom synthesis projects requiring specific boronic ester functionalities.

Basic Information

Product Name	2-Chloro-5-Methoxypyridine-4-Boronic Acid Pinacol Ester
CAS No.	2096336-34-2
Molecular Formula	C₁₂H₁₇BClNO₃
Molecular Weight	269.53 g/mol
Synonyms	2-Chloro-5-methoxypyridine-4-boronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-(2-chloro-5-methoxypyridin-4-yl)-1,3,2-dioxaborolane; (2-Chloro-5-methoxypyridin-4-yl)boronic acid pinacol ester; 2-Chloro-5-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; Pinacol (2-chloro-5-methoxypyridin-4-yl)boronate
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Methoxypyridine-4-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.