Description

2-[2-(Bromomethyl)-3-Chlorophenyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-value, multi-functional organoboron building block, essential for advanced synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern pharmaceutical and materials science research. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific halogenated aryl motifs.
• Material Science & OLED Development: Serves as a precursor for creating advanced organic light-emitting diode (OLED) materials and other functional polymers.
• Suzuki-Miyaura Cross-Coupling: The primary application is as a versatile boronic ester pinacol ester coupling partner for palladium-catalyzed reactions with aryl halides.
• Ligand & Catalyst Development: Utilized in the synthesis of novel bidentate ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology & Probe Synthesis: Enables the site-specific incorporation of functional groups into biomolecules for imaging and diagnostic applications.

Basic Information

Product Name	2-[2-(Bromomethyl)-3-Chlorophenyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	2096335-91-8
Molecular Formula	C13H17BBrClO2
Molecular Weight	346.44 g/mol
Synonyms	(2-Bromomethyl-3-chlorophenyl)boronic acid pinacol ester; 3-Chloro-2-(bromomethyl)phenylboronic acid pinacol ester; 2-(Bromomethyl)-3-chlorobenzeneboronic acid pinacol ester; 2-(2-Bromomethyl-3-chlorophenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane; 1-Chloro-2-(bromomethyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene; B-(2-(Bromomethyl)-3-chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2-[2-(Bromomethyl)-3-Chlorophenyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development. Each lot undergoes comprehensive analytical characterization including NMR (1H, 13C, 11B), HPLC, and mass spectrometry to confirm identity and purity. Certificates of Analysis (COA) with full analytical data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.