Description

2-Cyclopropylamino-5-Pyridineboronic Acid, Pinacol Ester is a high-value, protected boronic acid ester derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling efficient, selective cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to introduce the versatile pyridine-cyclopropylamine pharmacophore into target molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those targeting central nervous system (CNS) disorders and infectious diseases.
• Suzuki-Miyaura Cross-Coupling: A vital reagent for palladium-catalyzed carbon-carbon bond formation, facilitating the construction of biaryl and heterobiaryl structures prevalent in medicinal chemistry.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the biological activity of the cyclopropylamino-pyridine moiety.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as those used in OLEDs and conductive polymers, due to its conjugated system.
• Chemical Biology Probes: Useful for constructing molecular probes and tags for studying biological processes and protein interactions.

Basic Information

Product Name	2-Cyclopropylamino-5-Pyridineboronic Acid, Pinacol Ester
CAS No.	2096334-77-7
Molecular Formula	C14H19BN2O2
Molecular Weight	258.13 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-cyclopropylpyridin-2-amine; 2-(Cyclopropylamino)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-Cyclopropylamino-5-pyridinylboronic acid pinacol ester; N-Cyclopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine; 2-Amino-5-(dihydroxyboryl)pyridine pinacol ester, N-cyclopropyl deriv.; B-(6-(Cyclopropylamino)-3-pyridinyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-Cyclopropylamino-5-Pyridineboronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance in sensitive cross-coupling reactions. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.