Description

1-(4-Chloro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Piperidine is a high-value, advanced pharmaceutical intermediate featuring a boronic ester functional group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex carbon-carbon bonds. It is primarily sought after by research institutions and pharmaceutical companies engaged in the discovery and development of new active pharmaceutical ingredients (APIs), particularly for oncology and central nervous system (CNS) targets.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially for small molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the efficient and selective formation of biaryl and other conjugated systems essential in drug design.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry Development: Serves as a critical raw material for scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Agrochemical Synthesis: Potential intermediate in the development of advanced crop protection agents and herbicides.
• Material Science Research: Used in the synthesis of organic electronic materials and ligands for catalysts.

Basic Information

Item	Detail
Product Name	1-(4-Chloro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Piperidine
CAS No.	2096334-70-0
Molecular Formula	C18H27BClNO2
Molecular Weight	335.67 g/mol
Synonyms	1-[(4-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methyl]piperidine; 4-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl piperidine; 2-(4-Chloro-3-(piperidin-1-ylmethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1-(4-Chloro-3-(pinacolatoboryl)benzyl)piperidine; Piperidine, 1-[[4-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl]-; Boric acid, cyclic ester with 1-[(4-chloro-3-boronophenyl)methyl]piperidine, 2,2-dimethyl-1,3-propanediol
EINECS	Contact for details

Quality Control

Our 1-(4-Chloro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Piperidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for sensitive coupling reactions. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive nature. Allow the sealed container to reach room temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.