Description

1-(4-Fluoro-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)-n-Methylmethanamine is a high-purity, advanced pharmaceutical intermediate featuring a boronic ester pinacol group, which is critical for modern cross-coupling reactions like Suzuki-Miyaura. This compound matters because it provides a versatile and stable building block for constructing complex molecular architectures, enabling the efficient synthesis of novel active pharmaceutical ingredients (APIs). It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a crucial boron-containing coupling partner for forming carbon-carbon bonds between aromatic rings.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science & OLED Development: Acts as a building block for creating organic semiconductors and light-emitting materials for electronic displays.
• Chemical Biology & Proteolysis-Targeting Chimeras (PROTACs): Employed in the construction of bifunctional molecules for targeted protein degradation.
• Ligand Synthesis for Catalysis: Used to prepare sophisticated ligands for asymmetric catalysis and transition metal complexes.

Basic Information

Product Name	1-(4-Fluoro-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)-n-Methylmethanamine
CAS No.	2096334-69-7
Molecular Formula	C14H21BFNO2
Molecular Weight	265.13 g/mol
Synonyms	N-Methyl-1-[4-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanamine; 1-(4-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-N-methylmethanamine; 4-Fluoro-2-(N-methylaminomethyl)phenylboronic acid pinacol ester; (4-Fluoro-2-((methylamino)methyl)phenyl)boronic acid pinacol ester; 2-((Methylamino)methyl)-5-fluorophenylboronic acid pinacol ester; CAS 2096334-69-7
EINECS	Contact for details

Quality Control

Our 1-(4-Fluoro-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)-n-Methylmethanamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for sensitive coupling reactions. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label or COA. The material is light-sensitive and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.