Description

3-Fluoro-2-(n-Methylpiperazinomethyl)Phenylboronic Acid Pinacol Ester, Dihcl is a sophisticated boronic ester derivative, a key intermediate in modern synthetic chemistry. Its value lies in its dual functionality, combining a protected boronic acid group with a substituted piperazine moiety, making it a versatile building block for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of new active ingredients through cross-coupling reactions and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A critical precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially in kinase inhibitor and CNS-targeted therapeutic research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides, where the fluorine and piperazine groups contribute to biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers and organic electronic materials.
• Chemical Biology Probes: Employed in the synthesis of bioconjugates and molecular probes for studying biological pathways and protein interactions.
• Library Synthesis for Drug Discovery: A valuable scaffold for generating diverse compound libraries in high-throughput screening campaigns.
• Catalyst Ligand Development: The structural features can be utilized to develop novel ligands for transition metal catalysis.

Basic Information

Product Name	3-Fluoro-2-(n-Methylpiperazinomethyl)Phenylboronic Acid Pinacol Ester, Dihcl
CAS No.	2096334-62-0
Molecular Formula	C₁₈H₂₈BCl₂FN₂O₂
Molecular Weight	401.14 g/mol
Synonyms	3-Fluoro-2-[(4-Methylpiperazin-1-yl)methyl]phenylboronic Acid Pinacol Ester Dihydrochloride; 2-[(4-Methyl-1-piperazinyl)methyl]-3-fluorobenzeneboronic Acid Pinacol Ester Dihydrochloride; (3-Fluoro-2-{[(4-methylpiperazin-1-yl)methyl]})phenylboronic Acid Pinacol Ester 2HCl; B-[3-Fluoro-2-[(4-methyl-1-piperazinyl)methyl]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Dihydrochloride; 2096334-62-0; Pinacol 3-Fluoro-2-(N-Methylpiperazinomethyl)phenylboronate Dihydrochloride
EINECS	Contact for details

Quality Control

Our 3-Fluoro-2-(n-Methylpiperazinomethyl)Phenylboronic Acid Pinacol Ester, Dihcl is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our commitment to quality supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.