Description

2-Bromo-5-Methoxypyridine-4-Boronic Acid Pinacol Ester is a high-value, multi-functional organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, particularly Suzuki-Miyaura couplings, to construct complex heterocyclic scaffolds. This compound is critically needed by research and development chemists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of novel active ingredients and functional molecules. CAS No. 2096334-49-3.

Application

• Pharmaceutical Intermediate: A key synthon for constructing pyridine-based drug candidates in medicinal chemistry programs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides with pyridine cores.
• Material Science Research: Serves as a building block for creating organic electronic materials, ligands for catalysts, and metal-organic frameworks (MOFs).
• Suzuki-Miyaura Cross-Coupling: The pinacol ester group provides enhanced stability, making it a preferred reagent for palladium-catalyzed carbon-carbon bond formation.
• Library Synthesis: Enables high-throughput parallel synthesis for generating diverse compound libraries in early-stage discovery.
• Ligand and Catalyst Development: Used to synthesize complex chelating ligands for transition metal catalysis.

Basic Information

Product Name	2-Bromo-5-Methoxypyridine-4-Boronic Acid Pinacol Ester
CAS No.	2096334-49-3
Molecular Formula	C₁₂H₁₇BBrNO₃
Molecular Weight	314.0 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-bromo-5-methoxypyridine; 2-Bromo-5-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-Bromo-5-methoxypyridine-4-boronic acid pinacol ester; (2-Bromo-5-methoxypyridin-4-yl)boronic acid pinacol ester; 2-Bromo-5-methoxy-4-pyridineboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-5-Methoxypyridine-4-Boronic Acid Pinacol Ester is produced and tested under strict quality management protocols to ensure high purity and batch-to-batch consistency. Our standard grade typically meets a purity specification of ≥95% (by HPLC), with rigorous control of related substances and residual solvents. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), NMR data, and other critical parameters is provided with each shipment. Custom synthesis to meet specific pharmacopeial or internal standards is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability. Keep the container tightly sealed in a desiccator after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (H-NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.