Description

5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2,3-Dihydro-1H-Indole, Hcl is a high-purity, protected boronic ester derivative of 2,3-dihydro-1H-indole, serving as a critical synthetic intermediate. Its value lies in providing a stable, reactive handle for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex heterocyclic scaffolds. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries engaged in drug discovery and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing indole-based drug candidates targeting CNS disorders, oncology, and inflammation.
• Suzuki-Miyaura Cross-Coupling: Used as a boronic ester coupling partner to introduce the 2,3-dihydroindole moiety into complex molecules.
• Agrochemical Research: Intermediate in the development of novel herbicides, fungicides, and insecticides with heterocyclic cores.
• Material Science: Potential precursor for organic electronic materials and functional polymers requiring specific indole architectures.
• Chemical Biology & Proteomics: Useful for creating molecular probes and affinity tags to study biological systems.
• Academic & Contract Research: Enables synthetic methodology development and library synthesis for high-throughput screening.

Basic Information

Product Name	5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2,3-Dihydro-1H-Indole, Hcl
CAS No.	2096334-46-0
Molecular Formula	C14H21BClNO2
Molecular Weight	281.58 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-indole hydrochloride; 2,3-Dihydro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole hydrochloride; 5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)indoline hydrochloride; Indoline-5-boronic acid, pinacol ester, hydrochloride; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indoline HCl; CAS 2096334-46-0
EINECS	Contact for details

Quality Control

Our 5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2,3-Dihydro-1H-Indole, Hcl is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research and development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements, including those for cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.