Description

3-Chloro-5-Piperidinophenylboronic Acid, Pinacol Ester is a sophisticated boronic ester derivative, a crucial protected intermediate in modern synthetic chemistry. Its core value lies in enabling precise Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl scaffolds. This high-purity building block is essential for researchers and process chemists in pharmaceutical R&D and agrochemical discovery, where it facilitates the efficient synthesis of novel active compounds.

Application

• Pharmaceutical Intermediate: A key protected boronic acid reagent for constructing complex drug candidates, particularly those containing substituted biphenyl or heteroaryl motifs.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the piperidine and chlorophenyl groups can impart specific biological activity.
• Material Science Research: Serves as a building block for creating novel organic electronic materials, ligands for catalysts, or functionalized polymers.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and inhibitors for studying biological pathways and enzyme functions.
• Cross-Coupling Reactions: Specifically designed for use in palladium-catalyzed Suzuki-Miyaura couplings, offering improved stability and handling compared to the corresponding boronic acid.
• Library Synthesis for Drug Discovery: Enables the rapid, parallel synthesis of diverse compound libraries for high-throughput screening in medicinal chemistry programs.

Basic Information

Product Name	3-Chloro-5-Piperidinophenylboronic Acid, Pinacol Ester
CAS No.	2096334-12-0
Molecular Formula	C17H25BClNO2
Molecular Weight	321.65 g/mol
Synonyms	3-Chloro-5-(piperidin-1-yl)phenylboronic acid pinacol ester; 1-(3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine; 2-(3-Chloro-5-(piperidin-1-yl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Chloro-5-piperidin-1-ylbenzeneboronic acid pinacol ester; 3-Chloro-5-(1-piperidinyl)benzeneboronic acid pinacol ester; Boronic acid, B-[3-chloro-5-(1-piperidinyl)phenyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-Piperidinophenylboronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided to guarantee consistency and reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (typically 15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.